About $41 billion of the $50 billion over five years would be devoted to AIDS, significantly expanding a program credited with saving more than 1 million lives in Africa alone in the largest U.S. investment ever against a single disease.

Every day another 6,000 people are infected with the HIV virus, said House Foreign Affairs Committee Chairman Howard Berman, D-Calif. "We have a moral imperative to act and to act decisively," he said.

The House voted 308-116 to extend and broaden the scope of the $15 billion President's Emergency Plan for AIDS Relief that President Bush promoted and Congress enacted in 2003. It has been hailed as a noteworthy foreign policy success of the Bush presidency.

The White House, which backs the House bill, said the program is supporting anti-retroviral treatment for about 1.45 million people and is on track to meet its goals of backing treatment for 2 million, preventing 7 million new infections and providing care for 10 million, including orphans and vulnerable children.

In 2007, 33 million people worldwide were living with HIV and AIDS, according to the United Nations.

Rep. Ileana Ros-Lehtinen of Florida, top Republican on the Foreign Affairs Committee, added that while the program is based on altruism, it has strengthened U.S. security.

Without addressing the AIDS pandemic, she said, it "will continue to spread its mix of death, poverty and despondency that is further destabilizing governments and societies, and undermining the security of entire regions."

The compromise bill was one of the last endeavors of the former Foreign Affairs Committee chairman, Tom Lantos, D-Calif., who died of cancer in February. The measure is named after Lantos and his predecessor as Foreign Affairs chairman, the late Rep. Henry Hyde, R-Ill., who worked together on the 2003 act.

The Senate Foreign Relations Committee has approved a similar $50 billion bill, and the legislation is seen as having a good chance of passing in an election year in which few major bills will reach the president's desk.

To advance the legislation, conservatives had to give up a provision in the 2003 act requiring that one-third of all HIV prevention funds be spent on abstinence programs. Instead it directs the administration to promote "balanced funding for prevention activities" in target countries.

Liberals, in turn, had to accept some restrictions on family planning groups participating in AIDS programs. Conservatives, concerned that money might be diverted to abortion promotion, pushed for a provision that allows the use of funds for HIV/AIDS testing and counseling services in those family planning programs supported by the U.S. government.

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